Journal of Korean Society of Geriatric Neurosurgery 2007;3(1):66-71.
Published online June 30, 2007.
A Follow up Study on Comparison of Therapeutic Response of Bisphosphonates in Management of Osteoporotic Vertebral Compression Fracture
Bong Gil Seok , Jung Yul Park , Tae Young Cho, Dong Jun Lim , Sang Dae Kim

Department of Neurosurgery, Korea University Medical Center, Ansan Hospital, Korea

Abstract
Objective
Osteoporotic fractures are widely recognized as common and important causes of morbidity and mortality among elderly. The aim of this study was to compare the effects of bisphosphonates, namely alendronate and rispedronate, for the treatment on osteoporotic vertebral compression fracture (OVCF).
Materials
& Methods: A total of 245 patients were randomly divided into two groups; one with alendrnate treatment and the other with risperdronate treatment. This is an extension of previous study in which data from 74 patients were added to match the groups. Patients in Group A were allowed to take alandronate (70 mg/week) and patients in Group B with risedronate (30 mg/week). The follow up duration was at least 6 months. The efficacy of the treatment was evaluated by BMD measurements at spine and hip at 6 months and the degrees of compression fractures that were newly developed or were aggravated during study period. The statistical analysis was done by SPSS.
Results
During follow up period, 4 patients developed new OVCF (4.8%) and 10 patients showed aggravation of BMD score (12.1%) in alendronate group. In risedronate group, 4 patients developed new OVCF (5.5%) and 10 patients were aggravated with BMD scores (13.8%). Statistically, there were no meaningful differences (OVCF; p=0.765, BMD score; p=0.231) and these results were similar to our previous report.
Conclusion
These results indicate that there are no significant differences in number of newly developed OVCFs and BMD aggravation in two groups as previous study had shown.
Key Words: OsteoporosisㆍCompression fractureㆍRispedronateㆍAladronateㆍBMD


ABOUT
BROWSE ARTICLES
EDITORIAL POLICY
FOR CONTRIBUTORS
Editorial Office
21, Namdong-daero 774beon-gil, Namdong-gu, Incheon 21565, Korea
Tel: +82-32-460-3304    Fax: +82-32-460-3899    E-mail: editor@jksgn.org                

Copyright © 2024 by Korean Society of Geriatric Neurosurgery.

Developed in M2PI

Close layer
prev next