J Korean Soc Geriatr Neurosurg > Volume 16(1); 2020 > Article
Journal of Korean Society of Geriatric Neurosurgery 2020;16(1):7-11.
DOI: https://doi.org/10.51638/jksgn.20.00052    Published online September 30, 2020.
Risk Factor of Cerebral aneurysm and Correlation with Vitamin D Deficiency
Yong Jun Chung, Hak Sung Kim, Suk Jung Jang
Department of Neurosurgery, Chosun University College of Medicine, Gwangju, Korea
뇌동맥류의 위험 인자 및 비타민 D 결핍과의 상관 관계
정용준, 김학성, 장석정
조선대학교 의과대학 신경외과학교실
Correspondence:  Suk Jung Jang, Tel: +82-62-220-3126, Fax: +82-62-227-4575, 
Email: sjajang@chosun.ac.kr
Abstract
Objective
The purpose of this study is to prove that vitamin D supplementation can prevent aneurysm rupture in patients with unruptured aneurysms.
Methods
We reviewed medical record of 60 patients who were diagnosed as having cerebral aneurysm(ruptured or unruptured) among the patients and had vitamin D test. 60 patients who had no aneurysms were retrospectively analyzed as a control group. 60 patients with a diagnosis of aneurysm were divided into subgroups of subarachnoid hemorrhage due to ruptured cerebral aneurysm. Other risk factors such as age, sex, hypertension, diabetes, coronary artery disease, hyperlipidemia, drinking, smoking, body mass index, erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) were compared with vitamin D levels.
Results
In a total of 120 patients, vitamin D deficiency was confirmed in the majority of the subjects (12.74 ng/mL in the experimental group and 19.49 ng/mL in the control group). In the group of 60 patients with cerebral aneurysms, hypertension (p<0.047), Smoking (p<0.01), vitamin D deficiency (p<0.001) and CRP (p<0.025) were significant risk factors.
Conclusion
In patients with a cerebral aneurysm, vitamin D deficiency was significantly higher than in patients without cerebral aneurysms, suggesting that vitamin D supplementation may play a protective role in the development and rupture of the aneurysm.
Key Words: Vitamin D deficiency, Intracranial aneurysm, Risk factors of intracranial aneurysm, Vitamin D
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