| Association between Higher Urine Cotinine Level and Risk of Sarcopenia in Korean |
|
Jun-kyu Hwang1 , Sun-kyu Choi1 , In-bo Han2 , Yoon Ha1 |
|
1Department of Neurosurgery, Yonsei University College of Medicine, Seoul,
2Department of Neurosurgery, CHA Bundang Medical Center, CHA University, Seongnam, Korea |
|
|
| Abstract |
Objective
The objective of this study was to explore the association of tobacco smoke exposure to sarcopenia based on urine continine.
Methods
This is a cross-sectional study on the effects of tobacco exposure on low muscle mass by using data from the Korea National Health and Nutrition Examination Survey (KNHANES)V. The relationship between tobacco exposure and sarcopenia was examined in 754 Korean who participated in the KNHANES V, based on urine cotinine level. Sarcopenia was defined as appendicular skeletal muscle mass (ASM) divided by body weight (%) that was greater than 2 standard deviation below the mean for healthy adults. The odds ratios (ORs) for sarcopenia were calculated using multiple logistic regression according to urine cotinine level (group 1:>500 ng/ml, group 2: ≤500 ng/ml) after adjus ting for confounding variables.
Results
A total of 179 subjects were diagnosed with sarcopenia. The group 1 (active smokers, >500 ng/ml) had lower muscle mass than the group 2 (light, nondaily, or passive smokers, ≤500 ng/ml). In the multiple linear regressions, hypertension and urine cotinine level were statistically related to low muscle mass.
Conclusion
Urine cotinine level higher than 500 ng/ml shown in active smokers was significantly associated with increased risk of sarcopenia in Korean male. |
| Key Words:
Appendicular skeletal muscle mass, Smoking, Urine cotinine, Sarcopenia |
|
PDF Links
Download Citation
