| Clinical Significance of Severe Intracranial Arterial Calcification in Spontaneous Lobar Intracerebral Hemorrhage |
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Jae Wook Kim1 , Ki-Su Park1 , Taek-Kyun Nam1 , Yong-Sook Park1 , Jeong-Taik Kwon1 , Woong Jae Lee2 , Jun Soo Byun2 , Mi-Ju Kim3 , Jae Young Choe4 |
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Departments of 1Neurosurgery, 2Radiology Chung-Ang University College of Medicine, Seoul,
3Department of Obstetrics and Gynecology, Kyungpook National University School of Medicine, Daegu,
4Department of Pediatrics, Kyungpook National University School of Medicine, Daegu, Korea |
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| Abstract |
Objective
Intracranial arterial calcification (IAC) is a biomarker reflecting the severity of intracranial vascular atherosclerosis, and is known to be associated with ischemic stroke. However, any association between IAC and hemorrhagic stroke remains unknown. The purpose of this study was to assess whether there is an association between IAC and spontaneous intracerebral hemorrhage (ICH), and to investigate the clinical significance of IAC in spontaneous ICH.
Methods
Between January 2011 and June 2016, 235 patients with spontaneous ICH were divided into no IAC (0 point), mild/moderate IAC (1-3 points), and severe IAC (≥4 points) groups according to IAC scores using published methodology on the basis of brain computed tomography. The patients’ medical and radiological records were reviewed retrospectively.
Results
Severity of IAC by group was correlated with a higher proportion of female and older patients, higher systolic and diastolic BPs, and higher cholesterol levels, respectively (p<0.05). There was a statistically significant correlation between the severity of IAC and lobar ICH. More severe IAC groups showed a higher proportion of lobar ICH (no IAC: 4.6% versus mild/moderate IAC: 9.1% versus severe IAC: 57.1%, p<0.001). Additionally, univariate and multivariate analyses revealed that severe IAC was associated with lobar ICH (univariate: HR=27.467; 95% CI, 8.536-88.380; p<0.001; multivariate: HR=29.189; 95% CI, 8.873-96.020; p<0.001).
Conclusion
There might be a possible relationship between severe IAC and spontaneous lobar ICH, but further studies should be considered to investigate any positive correlation between IAC and lobar ICH. |
| Key Words:
Intracranial arterial diseases, Atherosclerosis, Calcification, Intracerebral hemorrhage |
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