| A Comparative Study for Single Session - and Hypofractionated - Stereotactic Radiosurgery in the Treatment of Intracranial Meningiomas |
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Joon-Ho Choi2 , Kyoung-Su Sung3 , Young-Min Choi4 , Young-Jin Song1,2 , Ki-Uk Kim1,2 |
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1Brain Tumor Institute, Medical Science Research Center, 2Neurosurgery, 3Neurosurgery, and 4Radiation Oncology,
Dong-A University College of Medicine, Pusan, Korea |
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| Abstract |
Objective
To investigate the clinical and radiologic outcomes of intracranial meningiomas treated with the single-session stereotactic radiosurgery (SRS) and the hypofractionated SRS by linear accelerator (LINAC), and to evaluate the safety and effectiveness of the hypofractionated SRS, compared to the single-session SRS.
Methods
We retrospectively analyzed 46 patients treated with the single-session SRS (Group A, N=22) and the hypofractionated SRS (Group B, N=24) by Novalis (BrainLab, Feldkirchen, Germany) from April 2008 to March 2013, who were consecutively followed up over at least one year. The foci of our investigation were the post-treatment peritumoral edema (PTE), radiation-induced necrosis (RIN), treatment failure, and local control rate after both SRSs.
Results
In Group A, the median volume of lesions was 2.88 cc (range, 0.31-10.87 cc) while that of Group B was 9.99 cc (range, 1.05-37.62). In Group B, nine patients showed the tumor volume over than 10 cc, but only one patient in Group A was 10.87 cc. In these 9 patients of Group B, 8 patients had tumors with irregular shapes adjacent to critical structures, and 5 pateints had obvious neurologic deficits prior to the therapy. In comparative results, the two groups had no statistical significance of the clinical relation in the post-treatment PTE, RIN, treatment failure, and local control rate.
Conclusion
The hypofractionated SRS achieved the similar results and offered excellent benefit to the patients with large tumor located in critical location, compared to the single-session SRS. For such tumors, in which single-session SRS may be hazardous, the hypofractionated SRS seems to be an effective and safe treatment option. |
| Key Words:
Stereotactic radiosurgery, Meningioma, Hypofractionated, Linac radiosurgery |
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