| Predictors of Long-term Cognitive Decline in Patients with Hypertensive Intracerebral Hemorrhage: 1 Year Follow-up |
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Hyoung Bae Jeon , Cheol Su Jwa |
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Department of Neurosurgery, National Medical Center, Seoul, Korea |
| 고혈압성 뇌출혈 환자들에서 장기적인 인지기능 저하의 예측 인자들: 1년 추적 관찰 |
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전형배·좌철수 |
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국립중앙의료원 신경외과 |
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| Abstract |
Objective
Cognitive decline following hypertensive intracerebral hemorrhage (ICH) is not well known. We tried to assess independent predictors of long-term cognitive decline after hypertensive ICH.
Methods
Between January 2011 and December 2013, 88 survivors (55 males, 33 females) who had experienced hypertensive ICH were retrospectively analyzed. Cognitive decline means ≤23 of mini-mental status examination score. Cognitive decline following hypertensive ICH was decided by checking mini-mental status examination (MMSE) and clinical dementia rating (CDR) after 1 year. We assessed various variables affecting cognitive decline after hypertensive ICH; initial NIHSS (National Institutes of Health Stroke Scale), initial GCS (Glasgow Coma Scale score), operation, hydrocephalus, recurrent ICH, subsequent ischemic stroke, epilepsy or epileptic medications etc. Multiple logistic regression analysis was performed for assessing independent predictors of long-term cognitive decline after hypertensive ICH.
Results
Twenty-six patients (29.5%) underwent decline of cognitive functions 1 year after hypertensive ICH. Initial NIHSS, initial GCS, operation, hydrocephalus were all statistically significant differences in the cognitive decline group in patients with hypertensive ICH (all p<0.001). Multiple logistic regression analysis revealed age (odds ratio [OR], 1.056; 95% confidence interval [CI], 1.007-1.107; p=0.026), initial GCS (OR, 0.610; 95% CI, 0.402-0.927; p=0.021) and operation (OR, 4.746; 95% CI, 1.063-21.190; p=0.041) were independent predictors of long-term cognitive decline following hypertensive ICH.
Conclusion
Age and initial mental status seem to be the important prognostic factors of long-term cognitive decline following hypertensive ICH. In the future, long-term large prospective analysis may be required. |
| Key Words:
Intracerebral hemorrhageㆍAgeㆍCognitive function |
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